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Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic Falciparum Malaria infections in Uganda

Journal

Journal of Infectious Diseases

Category: Publications

Author: Stephen Tukwasibwe, Levi Mugenyi, George W. Mbogo, Sheila Nankoberanyi, Catherine Maiteki-Sebuguzi, Moses L. Joloba, Samuel L. Nsobya, Sarah G. Staedke and Philip J. Rosenthal

Published Date: 19 January 2014

Summary

We explored associations between Plasmodium falciparum drug resistance–mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective case-control design. All 243 febrile children (cases) and 243 randomly selected asymptomatic children (controls) were included. In a multivariate analysis adjusting for age, complexity of infection, and parasite density, the prevalence of wild-type genotypes was significantly higher in febrile children compared to asymptomatic children (pfcrt K76T: odds ratio [OR] 4.41 [95% confidence interval {CI}, 1.28–15.1];pfmdr1 N86Y: OR 4.08 [95% CI, 2.01–8.31], and pfmdr1 D1246Y: OR 4.90 [95% CI, 1.52–15.8]), suggesting greater virulence for wild-type parasites.

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